Mitochondrial Dysfunction and Post-Exertional Malaise

This is a fascinating article. I think many of my readers would be interested in this.

EDS and Chronic Pain News & Info

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME

Though this article refers to Chronic Fatigue Syndrome, these symptoms often overlap with other chronic conditions, like Fibromyalgia.  Also, people with EDS are often suspected of having mitochondrial issues.

A patient who lacks post-exertional malaise as described below does not have mitochondrial dysfunction. This type of exhaustion is unique to mitochondrial problems.

It has been well documented that there is an abnormal increase in cytokines (chemicals released by the immune system) in CFS/ME patients following mild exercise. This causes another type of fatigue on top of the mitochondrial dysfunction fatigue discussed below. Cytokines in general, without the exercise trigger, can cause fatigue.  There are probably additional causes of fatigue (such as orthostatic intolerance) as well.

Role of mitochondria in cellular function

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  9 comments for “Mitochondrial Dysfunction and Post-Exertional Malaise

  1. May 8, 2014 at 5:20 am

    I thought you might like it!

    More amazing animations at this YouTube channel

    You might want to start with this one


  2. May 6, 2014 at 5:10 pm

    Oops, again. I obviously have no idea what I’m doing with YouTube. (I’m very sleep-deprived right now.)


  3. May 6, 2014 at 5:08 pm

    Oops, sorry. I didn’t know that I was embedding the video in the comment. I should have put

    Also, ‘id’ should read ‘if’.


    • May 8, 2014 at 4:18 am

      FABULOUS!!! Thanks for putting this in. I love what the cell pats do and the textures and colors, wow!


  4. May 5, 2014 at 8:02 pm

    Those sneaky little mitochondria, always acting so innocent!


    • May 6, 2014 at 4:50 am

      You crack me up.


      • May 6, 2014 at 5:03 pm

        I must admit that I couldn’t understand that piece at all–and I have a Bachelor’s Degree in Science!

        I don’t know id you’ve seen ‘The Inner Life of the Cell’.

        This video leaves me in awe and reminds me of how far we are from understanding health and disease.


  5. Leigh Prim
    May 3, 2014 at 2:25 pm

    Hi Kerry!

    This was good to read, Kerry, and thank you for sending it.  I can relate, in part, to some, and that is the part I concentrated upon.  I seldom deal with PEM anymore, but occasionally dig into why I cripple so much and my muscles are so unusable.  The two may be related.

    Thank you again! 

    Take good care, Leigh


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